Encrypt files using Microsoft Excel in Mac OS X. With your document open, select the File tab and from the drop-down menu, click passphrases. From the 'File passphrases' dialogue box, enter your desired passphrase in the 'passphrase to open' field.
Use the lastest versions of Excel only: Excel 2010 or Excel 2013. Use good password policies, which means longer passwords with different types of characters, numbers and symbols. In addition, try to make the password as random as possible and use a password manager to keep track of your passwords.
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It is recommended that you use a strong password or passphrase. Once finished, click OK. You are now prompted to confirm your passphrase by reentering it. Once finished, click OK. As the file is now encrypted, the passphrase will be required to open it.